Lekhok, K C and PRAJAPATI, D and Boruah, R C
(2008)
Indium(III) trifluoromethanesulfonate: An efficient reusable catalyst for the alkynylation-cyclization of 2-aminoaryl ketones and synthesis of 2,4-disubstituted quinolines.
Synlett (5).
pp. 655-658.
Abstract
An environmentally friendly and highly efficient procedure
for the preparation of 2,4-disubstituted quinoline derivatives
has been developed by a simple alkynylation 13cyclization reaction
of 2-aminoaryl ketones with phenylacetylenes in the presence of indium(
III) trifluoromethanesulfonate In(OTf)3 under microwave irradiation
and solvent-free conditions. This catalyst can be recovered
after the reaction and reused efficiently in subsequent runs.
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