DEB , M L and BHUYAN , P J
(2006)
Synthesis of novel classes of Pyrido[2,3-d]-pyrimidines, pyrano[2,3-d]pyrimidines, and pteridines.
Synthetic Communications, 36 (20).
pp. 3085-3090.
Abstract
6-Amino-5-formyluracils 1 and 5-formyl-6-hydroxyuracils 4 react with
Meldrum 19sacid2inthepresenceofpiperidineascatalystunderthermolyticconditions
to afford 6-carboxy-2,4,7-trioxopyrido[2,3-d]pyrimidines 3 and 6-carboxy-2,4,7trioxopyrano[2,3-d]pyrimidines
5 in good yield. Under identical conditions, 6-amino5-nitrosouracils
6 react with 2 to afford pteridine-6-carboxylic acids 7 in good yields.
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